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TSG101 ESCRT-I UEV domain P 717SAP 720 MVB sorting and viral budding CHMP4 ESCRT-III Unknown Bro 1, domain, Patch 1 MVB sorting and viral budding Gag YPx nL Unknown Viral budding SETA SH3 domain P 740TPAPR 745 Growth factor receptor endocytosis; focal adhesion remodeling Endophilin SH3 domain P 755ARPPPP 761 Growth factor receptor endocytosis Src SH2 domain Phospho-Y 319 Growth factor receptor endocytosis; focal adhesion remodeling Src SH3 domain P 752QPPAR 757 Growth factor receptor endocytosis; focal adhesion remodeling ALG-2 Unknown PGY repeats aa 802-813 Apoptosis Overview of the cellular mechanisms involving Alix.

In a two-step process, the SH2 domain of Src binds to a phosphotyrosine residue in the Bro1 domain of Alix; then the SH3 domain of Src binds to yet another proline-based motif in the C-terminal region of Alix.

With this blueprint in hand, we can now ask whether Alix acts simply as an adaptor that links different proteins into networks or, instead, contributes a specific function to distinct molecular machineries.

SUMMARY Meaghan has more than 15 years of experience as a forensic accountant, handling global investigations and providing litigation support, including testimony.

Alix is a cytosolic protein in mammalian cells that was originally identified on the basis of its association with pro-apoptotic signaling.

Src regulation of Alix Whereas Cbl and the SETA-endophilin complex bind only to activated EGFRs, Alix is constitutively associated with the receptor, albeit indirectly.

A separate proline-based motif in Alix binds to the SH3 domain of endophilins , which might aid sequestration of the SETA-endophilin complex.

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Alix also is enriched in virions that are released from cells under the direction of the HIV-1 Gag protein ;.

This indicates that a major function for Bro1 is to recruit Doa4 to the site of MVB cargo sorting.

Alternatively, it might interfere with the ability of SETA to promote focal adhesion formation, which would be similar to the way in which Alix restricts SETA from promoting EGFR endocytosis.