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Many investigators have suggested modifications to the RACE protocol to improve the effectiveness of the technique.

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Tal S, Ben Izhak M, Wachtel C, Wiseman A, Braun T, Yechezkel E, Golan E, Hadas R, Turjeman A, Banet-Noach C, Bronstein M, Lublin A, Berman E, Raviv Z, Pirak M, Klement E, Louzoun Y.

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Here, we describe a novel urea-based cross-linker, which allows distinguishing different cross-linking products by collision-induced dissociation CID tandem MS experiments based on characteristic product ions and constant neutral losses.